Tsunoda R, Yaginuma Y, Kojima M
Acta Pathol Jpn. 1980 Jan;30(1):33-57. doi: 10.1111/j.1440-1827.1980.tb01303.x.
The rate of presence of surface immunoglobulins (sIg) and incidence of the surface receptors (SRBC-receptor, Fc-receptor and C3 receptor) were examined on the constituent cells of secondary nodules enucleated from human tonsils and foated in suspension. As most of the rosette-forming cells for SRBC-receptor were judged to belong to small round cells, the germinal center was considered to be a "non-T-cell region." The coronal B-lymphocytes and small germinal center cells were fairly matured B-cells because both bore sIg (100%), Fc receptor (25%) and C3 receptor (90-80%), while the former cells were thought to be more matured on the basis of their possession of surface delta-chain. As the large germinal center cells bore sIg (50%) and carried Fc receptor (25%) and C3 receptor (50%), they seemed to be the major immature cells among the cell constituents of the secondary nodules. Moreover, it is presumed that the majority of the large germinal center cells are able to differentiate into coronal B-lymphocytes, probably memory cells, and a minor population of them into cIg-containing cells.
对从人扁桃体摘除并悬浮培养的次级淋巴小结的组成细胞，检测了表面免疫球蛋白（sIg）的存在率和表面受体（绵羊红细胞受体、Fc受体和C3受体）的发生率。由于大多数形成绵羊红细胞受体玫瑰花结的细胞被判定属于小圆形细胞，生发中心被认为是一个“非T细胞区域”。冠状B淋巴细胞和小生发中心细胞是相当成熟的B细胞，因为二者都带有sIg（100%）、Fc受体（25%）和C3受体（90 - 80%），而前者基于其表面δ链的存在被认为更成熟。大生发中心细胞带有sIg（50%），并具有Fc受体（25%）和C3受体（50%），它们似乎是次级淋巴小结细胞成分中的主要未成熟细胞。此外，推测大多数大生发中心细胞能够分化为冠状B淋巴细胞，可能是记忆细胞，其中少数细胞能分化为含胞内免疫球蛋白的细胞。
