Miyata M, Hamaji M, Yamamoto T, Nakao K, Sakaguchi H, Sakamoto T
Ann Surg. 1980 Mar;191(3):282-6. doi: 10.1097/00000658-198003000-00005.
In an attempt to elucidate changes in endocrine functions of the pancreas associated with radical pancreatectomy for periampullary cancer, plasma levels of insulin (IRI) and pancreatic glucagon (IRG) were measured during arginine infusion in ten patients with periampullary cancer both before and after pancreatoduodenectomy. The response of plasma IRI to arginine which was impaired before the surgery showed further impairment after the surgery. This finding is consistent with the previous results obtained in such patients by oral glucose tolerance testing. Also, the response of plasma IRG was subnormal preoperatively and was found to be impaired postoperatively. Both maximum and integrated secretion of IRG during arginine infusion decreased after the surgery in all instances. From these findings, it is concluded that pancreatoduodenectomy aggravates the already disordered pancreatic endocrine functions, as indicated by arginine infusion in patients with periampullary cancer.
为了阐明与壶腹周围癌根治性胰切除术相关的胰腺内分泌功能变化，在10例壶腹周围癌患者胰十二指肠切除术前后，于精氨酸输注期间测定了血浆胰岛素（IRI）和胰高血糖素（IRG）水平。术前血浆IRI对精氨酸的反应受损，术后进一步受损。这一发现与此前通过口服葡萄糖耐量试验在这类患者中获得的结果一致。此外，术前血浆IRG的反应低于正常水平，术后发现其受损。在所有情况下，术后精氨酸输注期间IRG的最大分泌量和综合分泌量均下降。从这些发现可以得出结论，如壶腹周围癌患者精氨酸输注所示，胰十二指肠切除术会加重已紊乱的胰腺内分泌功能。
