Gentilini P, Laffi G, Buzzelli G, Stefani P, Scarpelli P, Paladini S, Smorlesi C, La Villa G, Forti G
Digestion. 1980;20(2):73-8. doi: 10.1159/000198421.
83 patients with chronic active hepatitis (CAH), 38 of them with cirrhosis, were studied and compared with 10 control subjects suffering from chronic persistent hepatitis (CPH). Tubular acidosis frequently was found in our cases. Renal plasma flow and glomerular filtration rate were significantly decreased in CAH when compared with CPH. Selective renal arteriography showed evident decrease of arterial flow in the outer cortex. Selective renal scan with 99mTc microspheres of human albumin showed a frequent escape of the tracer from the kidney to the lung. PGE1 and PGE2 levels appeared higher in the renal artery than in the vein and were significantly more elevated in 9 cases with cirrhosis vs. 13 controls. These results suggest the frequent functional impairment of the kidney also in the early stages of CAH, with an increase of PGE levels and an opening of intrarenal shunts.
对83例慢性活动性肝炎（CAH）患者进行了研究，其中38例患有肝硬化，并与10例慢性持续性肝炎（CPH）对照受试者进行了比较。在我们的病例中经常发现肾小管酸中毒。与CPH相比，CAH患者的肾血浆流量和肾小球滤过率显著降低。选择性肾动脉造影显示肾外皮质动脉血流明显减少。用99mTc人白蛋白微球进行的选择性肾扫描显示示踪剂经常从肾脏逸出至肺部。肾动脉中PGE1和PGE2水平高于静脉，9例肝硬化患者与13例对照相比显著升高。这些结果表明，在CAH早期肾脏也经常出现功能损害，伴有PGE水平升高和肾内分流开放。
