Dabbs E R
Mol Gen Genet. 1980 Jan;177(2):271-6. doi: 10.1007/BF00267438.
The phenotype of a kasugamycin dependent mutant, MV17, was found to be the product of a kasugamycin resistance mutation in ksgA, together with a dependentizing mutation in rplW, the gene for large ribosomal subunit protein L23. Revertants from dependence on this small subunit targeted antibiotic were found to have mutational laterations in ribosomal proteins L23, L1, L11, and S9. The mutations causing alterations in L1 and L23 were shown to be responsible for the reversion and that altering L11 to be involved in the reversion.
发现卡那霉素依赖型突变体MV17的表型是ksgA中卡那霉素抗性突变的产物，同时rplW（编码核糖体大亚基蛋白L23的基因）中存在一个依赖化突变。从对这种靶向小亚基抗生素的依赖性中回复的菌株，在核糖体蛋白L23、L1、L11和S9中存在突变变化。导致L1和L23发生改变的突变被证明是回复的原因，而改变L11也参与了回复过程。
