Koch C D, Rommel K
Monatsschr Kinderheilkd (1902). 1980 Mar;128(3):118-22.
Considering the multitude of tests in clinical chemistry and hematology, their low diagnositc sensitivity and specifity, and the low incidence of the diseases in a non selected population it is not possible presently to recommend a general screening procedure based on the definition of the reference, the methodological reproducibility and the diagnostic information of a test procedure it is possible to calculate the number of requests necessary to get any desired number of pathological results. "Tell me how many pathological results you want and I'll tell you how many requests you need". In order to get an optimal diagnostic information for clinical chemistry and hematological tests, it is necessary to increase the prevalence by proper selection of the patients and then to order test procedures specific for the suspected disease.
考虑到临床化学和血液学中的大量检测项目、它们较低的诊断敏感性和特异性，以及在未经过筛选的人群中疾病的低发病率，目前不可能基于参考值的定义、方法的可重复性和检测程序的诊断信息推荐一种通用的筛查程序。可以计算出获得任何期望数量的病理结果所需的检测申请数量。“告诉我你想要多少病理结果，我就告诉你需要多少检测申请”。为了获得临床化学和血液学检测的最佳诊断信息，有必要通过适当选择患者来提高患病率，然后针对疑似疾病安排特定的检测程序。
