Prefaut C, Ramonatxo M, Monnier L, Mirouze J, Chardon G
Pathol Biol (Paris). 1980 Mar;28(3):149-54.
Spirometry, blood gases, steady state diffusing lung capacity for carbon monoxyde, ductance for carbon monoxyde were determined in 27 obeses. In 13 of them we also measured closing volume. In 80 per cent of these patients we observed a decrease in expiratory reserve volume certainly due to a shift on the right of the chest wall volume-pressure curve. In 50% of the obeses we found an arterial hypoxia, usually observed when the expiratory level was lower than closing volume. Finally in 20% of the subjects we observed a decrease in diffusing lung capacity and/or ductances probably due to an important fall in and expiratory level at the closing volume level with impairment of the distribution of ventilation.
对27名肥胖者进行了肺活量测定、血气分析、一氧化碳稳态肺扩散容量和一氧化碳传导率测定。其中13人还测量了闭合气量。在这些患者中,80%观察到呼气储备量减少,这肯定是由于胸壁容积-压力曲线右移所致。在50%的肥胖者中发现了动脉低氧血症,通常在呼气水平低于闭合气量时观察到。最后,在20%的受试者中,观察到肺扩散容量和/或传导率降低,这可能是由于在闭合气量水平时呼气水平大幅下降以及通气分布受损所致。