Karpe F, Bickerton A S, Hodson L, Fielding B A, Tan G D, Frayn K N
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Biochem Soc Trans. 2007 Jun;35(Pt 3):472-6. doi: 10.1042/BST0350472.
The triacylglycerol content of chylomicrons and VLDL (very-low-density lipoprotein) compete for the same lipolytic pathway in the capillary beds. Although chylomicron triacylglycerols appear to be the favoured substrate for lipoprotein lipase, VLDL particles compete in numbers. Methods to quantify the specific triacylglycerol removal from VLDL and chylomicrons may involve endogenous labelling of the triacylglycerol substrate with stable isotopes in combination with arteriovenous blood sampling in humans. Arteriovenous quantification of remnant lipoproteins suggests that adipose tissue with its high lipoprotein lipase activity is a principal site for generation of remnant lipoproteins. Under circumstances of reduced efficiency in the removal of triacylglycerols from lipoproteins, there is accumulation of remnant lipoproteins, which are potentially atherogenic.
乳糜微粒和极低密度脂蛋白（VLDL）中的三酰甘油含量在毛细血管床中竞争相同的脂解途径。尽管乳糜微粒三酰甘油似乎是脂蛋白脂肪酶的首选底物，但极低密度脂蛋白颗粒在数量上与之竞争。量化从极低密度脂蛋白和乳糜微粒中特异性去除三酰甘油的方法可能包括用稳定同位素对三酰甘油底物进行内源性标记，并结合人体动静脉血样采集。残余脂蛋白的动静脉定量分析表明，具有高脂蛋白脂肪酶活性的脂肪组织是残余脂蛋白生成的主要部位。在脂蛋白中三酰甘油去除效率降低的情况下，会有残余脂蛋白的积累，而残余脂蛋白可能具有致动脉粥样硬化作用。
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