西咪替丁治疗严重胃十二指肠出血：一项随机对照试验。

Cimetidine for severe gastroduodenal haemorrhage: a randomized controlled trial.

作者信息

Carstensen H E, Bülow S, Hansen O H, Jakobsen B H, Krarup T, Pedersen T, Raahave D, Svendsen L B, Backer O

出版信息

Scand J Gastroenterol. 1980;15(1):103-5. doi: 10.3109/00365528009181439.

Abstract

During a period of 12 months, 88 patients with severe haemorrhage from gastric or duodenal ulcers or from erosive gastritis completed a double-blind trial of either cimetidine or placebo. Only patients needing immediate blood transfusion were admitted to the trial. It was found that in patients with severe bleeding from gastric or duodenal ulcers neither the severity of bleeding nor the incidence of emergency surgery was reduced by cimetidine. Furthermore, the treatment did not improve the mortality rate. It is concluded that patients with severe bleeding from gastric or duodenal ulcers will not benefit from immediate treatment with intravenous cimetidine.

摘要

在12个月的时间里，88例因胃溃疡、十二指肠溃疡或糜烂性胃炎导致严重出血的患者完成了一项西咪替丁或安慰剂的双盲试验。只有需要立即输血的患者才被纳入试验。结果发现，对于胃溃疡或十二指肠溃疡严重出血的患者，西咪替丁既没有降低出血的严重程度，也没有降低急诊手术的发生率。此外，该治疗也没有提高死亡率。结论是，胃溃疡或十二指肠溃疡严重出血的患者不会从静脉注射西咪替丁的立即治疗中获益。