西咪替丁对十二指肠溃疡患者胃血流量增加的影响。
Effect of cimetidine on augmented gastric blood flow in duodenal ulcer patients.
作者信息
Ivarsson L, Darle N, Lundgren O
出版信息
Gut. 1984 Oct;25(10):1093-9. doi: 10.1136/gut.25.10.1093.
Blood flow in the human stomach was measured during operation with a 85Krypton washout method which made simultaneous determinations of total blood flow and intramural flow distribution possible. The antrum and the corpus of the stomach could be investigated separately. Eleven patients with duodenal ulcer disease were studied during pentagastrin infusion and after the addition of cimetidine, 3 mg/kg bw, to evaluate the effect of the drug on augmented gastric blood flow. Eight recordings were made over the corpus of the stomach and three recordings over the antrum. Cimetidine caused a 66 +/- 5% decrease (mean +/- SE; range 56-86) in acid secretion and a 62 +/- 5% decrease (range 44-91) in the corpus mucosal blood flow within 15 minutes. Changes were only seen in the acid secreting part of the stomach while the antral circulation remained unaltered. It is concluded that the decrease in pentagastrin induced vasodilatation in the stomach seen after giving cimetidine was secondary to an inhibition of acid secretion.
在手术过程中，采用⁸⁵氪洗脱法测量人体胃部的血流情况，该方法能够同时测定总血流量和壁内血流分布。胃窦和胃体可分别进行研究。对11例十二指肠溃疡患者在输注五肽胃泌素期间以及加入3mg/kg体重的西咪替丁后进行研究，以评估该药物对胃血流量增加的影响。在胃体进行了8次记录，在胃窦进行了3次记录。西咪替丁在15分钟内使胃酸分泌减少66±5%（平均值±标准误；范围56 - 86），胃体黏膜血流量减少62±5%（范围44 - 91）。变化仅出现在胃的泌酸部分，而胃窦循环未改变。得出的结论是，给予西咪替丁后，五肽胃泌素诱导的胃部血管舒张减弱是由于胃酸分泌受到抑制所致。
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