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T cell functional defect associated with thymid epithelial cell injury induced by a graft-versus-host reaction.

作者信息

Seddik M, Seemayer T A, Lapp W S

出版信息

Transplantation. 1980;29(1):61-6. doi: 10.1097/00007890-198001000-00013.

DOI:10.1097/00007890-198001000-00013
PMID:6989042
Abstract

The injection of parental strain cells into adrenalectomized (CBA x A)F1 mice induced a graft-versus-host (GVH) reaction which was morphologically characterized by thymus epithelial cell injury but not stress-related thymic involution. Thymocytes from mice undergoing a GVH reaction were studied for their ability to reconstitute allograft reactivity in thymectomized, irradiated, bone marrow reconstituted (ATxBM) (CBA x A)F1 mice. Thymocytes of mice experiencing a GVH reaction were theta-positive during the course of the reaction, however, by 40 days after GVH induction these thymocytes were unable to reconstitute allograft reactivity to H-2-incompatible skin grafts. It is proposed that GVH-induced thymic epithelial cell injury prevents or arrests normal T cell differentiation, resulting in a population of thymocytes which lack complete functional capability.

摘要

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