Hockel G M, Cowley A W
Adv Prostaglandin Thromboxane Res. 1980;7:1061-5.
The present investigation demonstrates that chronic intrarenal PGE2 infusion results in a PRA-induced increase in arterial pressure. This conclusion is supported by an 8-fold rise in PRA and the marked reduction of arterial pressure during saralasin and CEI infusion. If the chronic effects of endogenously released PGE2 are similar to arterial administration, then the net effect of chronically elevated renal PGE2 in the dog appears to be a moderate, sustained hypertension.
本研究表明，肾内持续输注前列腺素E2（PGE2）会导致肾素活性（PRA）诱导的动脉血压升高。PRA升高8倍以及在输注沙拉新和卡托普利（CEI）期间动脉血压显著降低支持了这一结论。如果内源性释放的PGE2的慢性效应与动脉给药相似，那么犬体内肾PGE2长期升高的净效应似乎是中度的持续性高血压。
