Effect of chronic intrarenal prostaglandin E2 infusion and angiotensin II blockade on arterial pressure in the dog.

The present investigation demonstrates that chronic intrarenal PGE2 infusion results in a PRA-induced increase in arterial pressure. This conclusion is supported by an 8-fold rise in PRA and the marked reduction of arterial pressure during saralasin and CEI infusion. If the chronic effects of endogenously released PGE2 are similar to arterial administration, then the net effect of chronically elevated renal PGE2 in the dog appears to be a moderate, sustained hypertension.