Cefalo R C, Lewis P E, O'Brien W F, Fletcher J R, Ramwell P W
Am J Obstet Gynecol. 1980 May 1;137(1):53-7. doi: 10.1016/0002-9378(80)90386-5.
The mechanism of respiratory distress in sepsis is unknown. Previous work has shown elevations of prostaglandins during sepsis. This study reveals a correlation between levels of prostaglandins F 2 alpha and E and pulmonary hypertension and other parameters of respiratory distress in oophorectomized ewes subjected to endotoxin. The use of prostaglandin synthetase inhibitors prior to endotoxin prevented the rise in prostaglandins and the development of respiratory distress.
脓毒症时呼吸窘迫的机制尚不清楚。先前的研究表明，脓毒症期间前列腺素水平会升高。本研究揭示了在接受内毒素注射的去卵巢母羊中，前列腺素F2α和E的水平与肺动脉高压及其他呼吸窘迫参数之间的相关性。在内毒素注射前使用前列腺素合成酶抑制剂可防止前列腺素水平升高及呼吸窘迫的发生。
