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Variability of short-term cultures of HeLa S-3 cells: changes in DNA distributions and rates of DNA synthesis.

作者信息

Collins J M, Berry D E, Bagwell C B

出版信息

Cell Tissue Kinet. 1980 May;13(3):277-85. doi: 10.1111/j.1365-2184.1980.tb00466.x.

DOI:10.1111/j.1365-2184.1980.tb00466.x
PMID:6989506
Abstract

DNA distributions of HeLa S-3 cells in spinner culture exhibit significant time-dependent changes. The major differences appear to occur in the S-phase region. Significant changes in the rates of DNA synthesis in several S-phase subcompartments correlated well with the changes in the DNA distributions. It is proposed that fluctuations in these rates of DNA synthesis are a reflection of the inherent instability of these abnormal, heteroploid cells.

摘要

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