Zigmond S H
Ciba Found Symp. 1980;71:299-311. doi: 10.1002/9780470720547.ch16.
The ability of polymorphonuclear leucocytes to respond to a chemical gradient has been examined by observing their behaviour in response to the peptide N-formylnorleucylleucylphenylalanine (f-NorleuLeuPhe). The cells appear to detect the direction of the chemical gradient by sensing differences in the number of their chemotactic receptors that are bound acroos their dimensions. When moving, a PMN has a polarized form with ruffles or pseudopods at the front and a knob-like tail at the rear. The potential for forming new pseudopods appears to exist in a gradient from anterior to posterior along the cell axis. Rapidly increasing the concentration of peptide can transiently induce the formation of ruffles over most of the cell surface except the tail. The presence of transient reversible responses to increases in the chemotactic factor suggests that with time the leucocyte adapts to the concentration of peptide to which it is exposed. A simple model which describes the cell polarity and adaptation is presented.
通过观察多形核白细胞对肽N-甲酰基去甲亮氨酰亮氨酰苯丙氨酸（f-NorleuLeuPhe）的反应行为，研究了其对化学梯度作出反应的能力。细胞似乎通过感知其趋化受体在其整个维度上结合数量的差异来检测化学梯度的方向。移动时，多形核白细胞呈极化形态，前端有褶皱或伪足，后端有球状尾巴。沿着细胞轴从前到后似乎存在形成新伪足的潜力梯度。快速增加肽的浓度可短暂诱导除尾巴外的大部分细胞表面形成褶皱。对趋化因子增加存在短暂可逆反应表明，随着时间推移，白细胞会适应其暴露的肽浓度。本文提出了一个描述细胞极性和适应性的简单模型。
