• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

各种物种对动脉粥样硬化易感性的差异是由于前列环素（PGI2）生成的先天性差异所致吗？

Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation.

作者信息

Sinzinger H, Clopath P, Silberbauer K, Winter M

出版信息

Experientia. 1980 Mar 15;36(3):321-3. doi: 10.1007/BF01952302.

DOI:10.1007/BF01952302
PMID:6989625
Abstract

Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.

摘要

对动脉粥样硬化发展表现出较高易感性的物种，其动脉壁中前列环素（PGI2）的生成减少，而这在血管系统的不同部位存在差异。由于PGI2形成在各种疾病中的差异是一种全身性血管效应，因此在所有血管中都能检测到这种变化。这对人类诊断而言是非常重要的一点。

相似文献

1
Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation.各种物种对动脉粥样硬化易感性的差异是由于前列环素（PGI2）生成的先天性差异所致吗？
Experientia. 1980 Mar 15;36(3):321-3. doi: 10.1007/BF01952302.
2
Platelet adhesion and mural platelet thrombus formation on aortic subendothelium of rats, rabbits, and guinea pigs correlate negatively with the vascular PGI2 production.大鼠、兔和豚鼠主动脉内皮下的血小板黏附和壁血小板血栓形成与血管前列环素（PGI2）的产生呈负相关。
J Lab Clin Med. 1981 Sep;98(3):402-11.
3
Increased prostacyclin-like activity in vascular tissues from rats on long-term treatment with an oestrogen-progestagen combination.长期接受雌激素 - 孕激素联合治疗的大鼠血管组织中类前列环素活性增加。
Thromb Res. 1979;14(4-5):793-7. doi: 10.1016/0049-3848(79)90134-8.
4
The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits.在兔实验性动脉粥样硬化中，动脉及冠状血管床生成前列环素的能力降低。
Prostaglandins. 1977;14(6):1025-34. doi: 10.1016/0090-6980(77)90282-9.
5
Inhibition of vascular epoprostenol (prostacyclin, PGI2) production in vitro by plasma from healthy subjects and patients with severe renal impairment.健康受试者和重度肾功能不全患者的血浆对体外血管前列环素（前列环素，PGI2）生成的抑制作用。
Br J Clin Pharmacol. 1982 Sep;14(3):379-83. doi: 10.1111/j.1365-2125.1982.tb01994.x.
6
Prostacyclin synthesis by vascular tissue. Effect of extracellular Ca2+.血管组织中前列环素的合成。细胞外钙离子的作用。
Biochem J. 1986 Oct 1;239(1):237-9. doi: 10.1042/bj2390237.
7
Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta.来自动脉粥样硬化兔主动脉的培养平滑肌细胞产生前列环素。
Nature. 1980 Jun 12;285(5765):480-2. doi: 10.1038/285480a0.
8
Stimulation of prostacyclin production in blood vessels by the antithrombotic drug suloctidil.抗血栓药物舒洛地尔对血管中前列环素生成的刺激作用。
Biochem Pharmacol. 1987 May 15;36(10):1629-35. doi: 10.1016/0006-2952(87)90047-5.
9
Uncontrolled PGI2 production by whole vessel wall segments due to thrombin generation in vivo and its prevention by heparin.体内凝血酶生成导致整个血管壁段PGI2产生不受控制及其被肝素预防。
Thromb Res. 1979;16(3-4):551-5. doi: 10.1016/0049-3848(79)90102-6.
10
Differences in inhibition of PGI2 production by aspirin in rabbit artery and vein segments.
Thromb Res. 1980 Nov 15;20(4):447-60. doi: 10.1016/0049-3848(80)90283-2.

引用本文的文献

1
Role of shear stress and stretch in vascular mechanobiology.切应力和拉伸在血管力学中的作用。
J R Soc Interface. 2011 Oct 7;8(63):1379-85. doi: 10.1098/rsif.2011.0177. Epub 2011 Jul 6.
2
Butter-enriched diets reduce arterial prostacyclin production in rats.
Lipids. 1988 Mar;23(3):234-41. doi: 10.1007/BF02535464.

本文引用的文献

1
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.动脉壁从前列腺素内过氧化物生成一种物质（前列腺素X），该物质可使肠系膜动脉和腹腔动脉条松弛，并抑制血小板聚集。
Prostaglandins. 1976 Dec;12(6):897-913. doi: 10.1016/0090-6980(76)90125-8.
2
Formation of prostacyclin (PGl2) by different layers of the arterial wall.动脉壁不同层对前列环素（PGl2）的生成。
Arch Int Pharmacodyn Ther. 1977 May;227(1):162-3.
3
Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.
前列环素（PGX）是由花生四烯酸诱导冠状动脉舒张的内源性代谢产物。
Prostaglandins. 1977 Jan;13(1):3-15. doi: 10.1016/0090-6980(77)90037-5.
4
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.脂质过氧化物会抑制血管微粒体中的一种酶，该酶能从前列腺素内过氧化物生成一种可防止血小板聚集的物质（前列腺素X）。
Prostaglandins. 1976 Nov;12(5):715-37. doi: 10.1016/0090-6980(76)90048-4.
5
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.动脉壁可通过一种由前列腺素内过氧化物生成的物质（前列腺素X）来防止血小板血栓的沉积。
Prostaglandins. 1976 Nov;12(5):685-713. doi: 10.1016/0090-6980(76)90047-2.
6
Relative potency of prostacyclin, prostaglandin E1 and D2 as inhibitors of platelet aggregation in several species [proceedings].前列环素、前列腺素E1和D2在几种物种中作为血小板聚集抑制剂的相对效力[会议论文集]
J Physiol. 1977 Dec;273(2):2P-4P.
7
Decreased vascular prostacyclin in juvenile-onset diabetes.青少年发病型糖尿病中血管前列环素减少。
N Engl J Med. 1979 Feb 15;300(7):366-7.
8
[Prostacyclin--inhibitory effect on thrombocyte aggregation on the vascular wall in vivo?].[前列环素——对体内血管壁上血小板聚集的抑制作用？]
Vasa. 1978;7(4):350-9.
9
PGI2 production by rat blood vessels: diminished prostacyclin formation in veins compared to arteries.大鼠血管中前列环素（PGI2）的生成：与动脉相比，静脉中前列环素的生成减少。
Prostaglandins. 1978 Jul;16(1):1-16. doi: 10.1016/0090-6980(78)90196-x.
10
Prostaglandin I2 has more potent hypotensive properties than prostaglandin E2 in the normal and spontaneously hypertensive rat.在正常大鼠和自发性高血压大鼠中，前列腺素I2比前列腺素E2具有更强的降压特性。
Prostaglandins. 1978 Jun;15(6):999-1003. doi: 10.1016/0090-6980(78)90042-4.