Pace-Asciak C R, Carrara M C, Nicolaou K C
Prostaglandins. 1978 Jun;15(6):999-1003. doi: 10.1016/0090-6980(78)90042-4.
The blood pressure lowering effects on PGI2 in the normal and spontaneously hypertensive rat are described. Comparison of dose response curves for PGI2 and PGE2 indicate that PGI2 is twice as potent as PGE2 in the normal rat and 3--4 times more active in the spontaneously hypertensive rat. Furthermore PGI2 is equiactive through intracarotid and intrajugular administration indicative of the complete lack of pulmonary inactivation. These findings supported by evidence of enhanced PGI2 synthesis in aorta during hypertension support the notion that PGI2 could participate in blood pressure control mechanisms.
描述了前列环素（PGI2）对正常大鼠和自发性高血压大鼠的降压作用。PGI2和前列腺素E2（PGE2）剂量反应曲线的比较表明，PGI2在正常大鼠中的效力是PGE2的两倍，在自发性高血压大鼠中的活性高3 - 4倍。此外，通过颈内和颈静脉给药，PGI2具有同等活性，表明完全没有肺内失活。高血压期间主动脉中PGI2合成增强的证据支持了这些发现，支持PGI2可能参与血压控制机制的观点。
