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尿低聚糖可抑制大肠杆菌对犬尿道上皮的黏附。

Urinary oligosaccharides inhibit adhesion of E. coli onto canine urinary tract epithelium.

作者信息

Järvinen A K, Sandholm M

出版信息

Invest Urol. 1980 May;17(6):443-5.

PMID:6989784
Abstract

Canine urine fractions were tested for their capacity to release Escherichia coli from everted canine ureteral segments. Urine was effective in detaching epithelially-bound E. coli; the active principle was a small molecular weight carbohydrate. Treatment with lectins decreased the degree of E. coli surface colonization, which confirms the importance of the mucosal glycocalyx in adhesion. The adhesion-inhibition by the active components may be by competition, which implies that the bacteria-releasing sugars resemble the determinant sugar moieties on the epithelial glycocalyx.

摘要

对犬尿液成分进行了检测,以评估其从外翻的犬输尿管段释放大肠杆菌的能力。尿液能够有效分离上皮细胞结合的大肠杆菌;活性成分是一种小分子碳水化合物。用凝集素处理可降低大肠杆菌在表面的定植程度,这证实了黏膜糖萼在黏附中的重要性。活性成分的黏附抑制作用可能是通过竞争实现的,这意味着释放细菌的糖类类似于上皮糖萼上的决定性糖部分。

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