Tiurina E V
Kardiologiia. 1980 Apr;20(4):60-4.
Changes in the sequence of the stimulation of the epicardial surface of a transplanted heart were studied on a heterotopic model in dogs in different periods after the operation. It was found that in the first hours the disturbances in stimulation are diffuse, but later they are of a more restricted character. These disturbances disappear completely by the 2nd day. On the 3rd-4th day the disorders of stimulation conduction reappear in limited areas, which corresponds with the developing focal morphological changes. The gradual increase in the area of disturbed stimulation conduction and in the intensity of the damage by the time of the rejection crisis were attended by a decrease of the P wave amplitude, deceleration of heart beats, development of atrioventricular block, the occurrence of heterotopic impulses, and disorganization of ventricular stimulation.
在犬的异位心脏移植模型上，研究了术后不同时期移植心脏心外膜表面刺激顺序的变化。结果发现，术后最初几个小时，刺激紊乱是弥漫性的，但之后其特征更为局限。这些紊乱在术后第2天完全消失。在第3 - 4天，刺激传导障碍在有限区域再次出现，这与正在发展的局灶性形态学变化相符。到排斥反应期时，刺激传导受扰区域逐渐扩大，损伤强度增加，同时伴有P波振幅降低、心率减慢、房室传导阻滞形成、异位冲动出现以及心室刺激紊乱。
