Solt A K, Neale S
Mutat Res. 1980 Apr;70(2):167-71. doi: 10.1016/0027-5107(80)90156-6.
Following administration of Natulan and Escherichia coli to mice a dose-dependent increase in the frequency of induced bacterial mutations was observed. This mutation response was dependent on the route of Natulan administration and, following short exposures, was limited by the rate of metabolic activation of the compound.
给小鼠注射纳突兰(Natulan)和大肠杆菌后,观察到诱导细菌突变频率呈剂量依赖性增加。这种突变反应取决于纳突兰的给药途径,并且在短期接触后,受该化合物代谢活化速率的限制。