Lackner F, Schüpbach M E
Mutat Res. 1981 Nov;90(3):247-54. doi: 10.1016/0165-1218(81)90004-5.
Natulan R (MIH, procarbazine) was tested for its ability to induce prophage lambda in Escherichia coli GY5027. E. coli Gy4015 served as indicator strain. A weak phage-inducing effect was observed at concentrations from 2 to 12 mg/plate in presence of S9 prepared from rats. This effect was found not to be due to the formation of hydrogen peroxide. It was confirmed that, even at the same high concentrations, no mutagenic effect can be detected with the Ames test in strains TA98 and TA100 of S. typhimurium. However, a toxic effect was observed in presence of S9 in S. typhimurium.
对纳吐兰R（甲苄肼，MIH）诱导大肠杆菌GY5027中λ原噬菌体的能力进行了测试。大肠杆菌Gy4015用作指示菌株。在存在从大鼠制备的S9的情况下，在浓度为2至12毫克/平板时观察到较弱的噬菌体诱导作用。发现这种作用不是由过氧化氢的形成引起的。已证实，即使在相同的高浓度下，用鼠伤寒沙门氏菌TA98和TA100菌株进行的艾姆斯试验也检测不到诱变作用。然而，在鼠伤寒沙门氏菌中存在S9的情况下观察到了毒性作用。
