Larimer F W, Hardigree A A, Lijinsky W, Epler J L
Mutat Res. 1980 Feb;77(2):143-8. doi: 10.1016/0165-1218(80)90131-7.
The mutagenic properties of 8 N-nitrosopiperazines were examined in Saccharomyces cerevisiae. Forward mutations to canavanine resistance and reversions of his1-7 were induced by N'-methyl-N-nitrosopiperazine, dinitrosopiperazine, 2-methyldinitrosopiperazine, 2,5-dimethyldinitrosopiperazine, and 2,6-dimethyldinitrosopiperazine, in the presence of rat-liver homogenate. N-nitrosopiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, and 4-benzoyl-3,5-dimethyldinitrosopiperazine were non-mutagenic.
在酿酒酵母中检测了8种N-亚硝基哌嗪的诱变特性。在大鼠肝脏匀浆存在的情况下，N'-甲基-N-亚硝基哌嗪、二亚硝基哌嗪、2-甲基二亚硝基哌嗪、2,5-二甲基二亚硝基哌嗪和2,6-二甲基二亚硝基哌嗪可诱导产生对刀豆氨酸抗性的正向突变以及his1-7的回复突变。N-亚硝基哌嗪、2,3,5,6-四甲基二亚硝基哌嗪和4-苯甲酰基-3,5-二甲基二亚硝基哌嗪无诱变作用。
