大鼠妊娠后期羊水、蜕膜组织及胎盘中血栓素B2和6-氧代前列腺素F1α的浓度。

Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat.

作者信息

Zamecnik J, Kennedy T G, Armstrong D T

出版信息

Adv Prostaglandin Thromboxane Res. 1980;8:1423-9.

Abstract

To determine if the levels of TXA2 and PGI2 within the uterus change at parturition in rats, the concentrations of their respective stable products, TXB2 and 6-oxo-PGF1 alpha (6-k-PGF1 alpha) were measured in amniotic fluid, decidual and placental tissues by specific radioimmunoassays which have been verified by gas chromatography-mass spectrometry. Samples were collected on days 15, 20, 21, and 22 of pregnancy and during labor on day 23. In general, levels of TXB2 and 6-k-PGF1 alpha as well as those of PGE and PGF were highest during labor on day 23, although levels of TXB2 and 6-k-PGF1 alpha in amniotic fluid and decidual tissue, respectively, peaked on day 22. The concentrations were generally highest in decidual tissue, and lowest in amniotic fluid. These findings suggest that TXA2 and PGI2 may have a role in parturition in rats.

摘要

为了确定大鼠分娩时子宫内血栓素A2（TXA2）和前列环素（PGI2）的水平是否发生变化，通过经气相色谱-质谱法验证的特定放射免疫分析法，测定了羊水、蜕膜和胎盘组织中它们各自稳定产物血栓素B2（TXB2）和6-酮-前列腺素F1α（6-k-PGF1α）的浓度。在妊娠第15、20、21和22天以及第23天分娩期间采集样本。总体而言，尽管羊水和蜕膜组织中TXB2和6-k-PGF1α的水平分别在第22天达到峰值，但TXB2、6-k-PGF1α以及前列腺素E（PGE）和前列腺素F（PGF）的水平在第23天分娩期间最高。这些浓度通常在蜕膜组织中最高，在羊水中最低。这些发现表明TXA2和PGI2可能在大鼠分娩中起作用。