肾上腺素能激动剂对大、小肾素的作用。
Effect of adrenergic agonists on big and small renin.
作者信息
Iwao H, Lin C S, Michelakis A M
出版信息
Am J Physiol. 1980 May;238(5):E416-20. doi: 10.1152/ajpendo.1980.238.5.E416.
The effect of alpha- and beta-adrenergic agonists on renal and submaxillary renin of different molecular weights was studied using male albino mice as experimental animals. Phenylephrine or isoproterenol was administered intravenously after removal of the submaxillary glands and/or kidneys. Renin was isolated from plasma by column chromatography and then measured by a direct radioimmunoassay. Phenylephrine increased both 68,500-dalton renin (big renin) and 38,000-dalton renin (small renin) in the plasma of nephrectomized mice. Isoproterenol increased big and small renin in the plasma of mice whose submaxillary glands were removed. In both cases, the increase of small renin was significantly greater than that of big renin. The results suggest that the alpha-adrenergic agonist phenylephrine affects the submaxillary gland, leading to the increase of both big and small plasma renin. In contrast, the beta-adrenergic agonist isoproterenol affects the kidney, leading to the increase of both big and small plasma renin.
以雄性白化小鼠作为实验动物，研究了α-和β-肾上腺素能激动剂对不同分子量的肾素及颌下腺肾素的影响。在摘除颌下腺和/或肾脏后，静脉注射去氧肾上腺素或异丙肾上腺素。通过柱色谱法从血浆中分离肾素，然后用直接放射免疫分析法进行测定。去氧肾上腺素使肾切除小鼠血浆中68,500道尔顿的肾素（大肾素）和38,000道尔顿的肾素（小肾素）均增加。异丙肾上腺素使摘除颌下腺的小鼠血浆中大肾素和小肾素增加。在这两种情况下，小肾素的增加均显著大于大肾素。结果表明，α-肾上腺素能激动剂去氧肾上腺素影响颌下腺，导致血浆中大肾素和小肾素均增加。相比之下，β-肾上腺素能激动剂异丙肾上腺素影响肾脏，导致血浆中大肾素和小肾素均增加。
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