α-和β-肾上腺素能刺激大鼠颌下腺的体外代谢效应。
Metabolic effect of alpha-and the beta-adrenergic stimulation of rat submaxillary gland in vitro.
作者信息
Thompson M P, Williamson D H
出版信息
Biochem J. 1976 Dec 15;160(3):597-601. doi: 10.1042/bj1600597.
Abstract
- Incubation of submaxillary-gland slices with isoproterenol, a beta-adrenergic agonist, stimulated glucose removal by 41% and decreased tissue [glucose 6-phosphate] by 50%. Propranolol blocked these effects of isoproterenol. 2. Phenylephrine, an alpha-adrenergic agonist, stimulated glucose removal by 35% and decreased tissue [glucose 6-phosphate] by 75%. In addition, phenylephrine also completely overcame the inhibition of pyruvate removal caused by acetoacetate metabolism and decreased tissue [atp] by 45%. Phentolamine blocked the effects of phenylephrine. 3. In contrast with beta-adrenergic stimulation, alpha-adrenergic stimulation required exogenous Ca2+. 4. These results explain the different metabolic responses of the submaxillary gland to adrenaline in the presence and absence of exogenous Ca2+.
摘要
- 用β-肾上腺素能激动剂异丙肾上腺素孵育颌下腺切片，可使葡萄糖清除率提高41%，并使组织中[6-磷酸葡萄糖]降低50%。普萘洛尔可阻断异丙肾上腺素的这些作用。2. α-肾上腺素能激动剂去氧肾上腺素可使葡萄糖清除率提高35%，并使组织中[6-磷酸葡萄糖]降低75%。此外，去氧肾上腺素还能完全克服由乙酰乙酸代谢引起的丙酮酸清除抑制，并使组织中[三磷酸腺苷]降低45%。酚妥拉明可阻断去氧肾上腺素的作用。3. 与β-肾上腺素能刺激相反，α-肾上腺素能刺激需要外源性钙离子。4. 这些结果解释了在有和没有外源性钙离子存在的情况下，颌下腺对肾上腺素的不同代谢反应。
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Enzyme secretion mediated by the epinephrine -receptor in rat parotid slices. Factors governing efficiency of the process.大鼠腮腺切片中肾上腺素受体介导的酶分泌。影响该过程效率的因素。
J Biol Chem. 1973 Jan 10;248(1):356-60.
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Regulation of protein secretion and metabolism in rat salivary glands. Effects of norepinephrine and carbachol on the glycogenolysis in submaxillary glands.大鼠唾液腺中蛋白质分泌和代谢的调节。去甲肾上腺素和卡巴胆碱对下颌下腺糖原分解的影响。
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