Cresteil T, Leroux P
Ann Biol Clin (Paris). 1980;38(1):57-65.
The hepatic or extra-hepatic mono-oxygenase activities ensure the metabolism of exogenic hydrophobic substances (xenobiotics) and endogenic substances (steroids). These substances easily cross the placenta ; it is of primary importance to know perfectly their possible transformation at the level of the foetus together with their excretion from the foetal compartment. We summarise here the data in the literature which describe the development of the mono-oxygenase system and the microsomal enzyme activities of phase II (epoxide hydrolase and UDP-glucuronosyl-transferase) both in the laboratory animal and in the human foetus. The influence of various factors (exogenic inducers, endogenic hormones) on the development of these activities is also reported. Although a conclusion is difficult concerning the present state of our knowledge, the main pharmacotoxicological consequences of the development of mono-oxygenasic activities are considered.
肝脏或肝外单加氧酶活性确保外源性疏水物质（异生物素）和内源性物质（类固醇）的代谢。这些物质很容易穿过胎盘；全面了解它们在胎儿体内可能发生的转化以及从胎儿体内的排泄情况至关重要。在此，我们总结文献中的数据，这些数据描述了实验动物和人类胎儿中单加氧酶系统的发育以及Ⅱ相微粒体酶活性（环氧化物水解酶和UDP-葡萄糖醛酸基转移酶）。还报道了各种因素（外源性诱导剂、内源性激素）对这些活性发育的影响。尽管就我们目前的知识状况而言很难得出结论，但还是考虑了单加氧酶活性发育的主要药物毒理学后果。
