Mansuy D
Ann Biol Clin (Paris). 1980;38(1):19-23.
The mechanism of action of mono-oxygenases of the biotransformation system of exogenic compounds is described emphasising two characteristics which are at the root of the implications of this system in pharmacology and toxicology : its non-specificity with regard to substrates and its great chemical reactivity. The consequences of the biotransformation of a drug (modulation of its therapeutic effect, appearance of noxious side-effects due to the formation of reactive metabolites) are illustrated by a few examples. Finally, the various mechanisms by which a drug may modify biotransformation and the effects of a second drug given in association, are analysed.
描述了外源性化合物生物转化系统中单加氧酶的作用机制，重点强调了该系统在药理学和毒理学中具有重要意义的两个特征：对底物的非特异性及其强大的化学反应性。通过几个例子说明了药物生物转化的后果（其治疗效果的调节，由于反应性代谢物的形成而出现有害副作用）。最后，分析了药物可能改变生物转化的各种机制以及联合使用第二种药物的效果。
