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小鼠肾脏对聚集免疫球蛋白的摄取。I. 内毒素的作用。

Uptake of aggregated immunoglobulin by the mouse kidney. I. Effect of endotoxin.

作者信息

Shvil Y, Michael A F, Mauer S M

出版信息

Br J Exp Pathol. 1980 Feb;61(1):22-9.

PMID:6990951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041558/
Abstract

Endotoxin (ET) pretreatment of mice resulted in increased liver and spleen uptake and decreased circulating levels of aggregated IgC (AggIgG) compared to control animals. ET had no effect upon the uptake of AggIgG by lung or whole kidney cortex. However, immunofluorescent microscopy revealed increased localization of AggIgG in the mesangium of ET mice at 1 but not at 2 or 16 h after administration of AggIgG. These studies show that mesangial macromolecular uptake is not solely dependent upon blood levels, but appears to be influenced by unknown and probably complex variables.

摘要

与对照动物相比，内毒素（ET）预处理的小鼠肝脏和脾脏摄取增加，循环中聚集IgC（AggIgG）水平降低。ET对肺或整个肾皮质摄取AggIgG没有影响。然而，免疫荧光显微镜显示，给予AggIgG后1小时，ET小鼠肾小球系膜中AggIgG的定位增加，但在2小时或16小时时没有增加。这些研究表明，肾小球系膜大分子摄取不仅取决于血液水平，而且似乎受到未知且可能复杂的变量的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/8083adb8cac6/brjexppathol00115-0036-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/c52a9c5e4025/brjexppathol00115-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/71a93fb40e41/brjexppathol00115-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/8083adb8cac6/brjexppathol00115-0036-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/c52a9c5e4025/brjexppathol00115-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/71a93fb40e41/brjexppathol00115-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7a0/2041558/8083adb8cac6/brjexppathol00115-0036-c.jpg

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本文引用的文献

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Relations of the centrolobular region of the glomerulus to the juxtaglomerular apparatus.肾小球小叶中心区域与球旁器的关系。
J Ultrastruct Res. 1962 Jun;6:562-78. doi: 10.1016/s0022-5320(62)80010-0.
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TRANSPORT OF GLOBIN BY THE RENAL GLOMERULUS.肾小球对珠蛋白的转运
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Localization of colloidal substances in vascular endothelium: a mechanism of tissue damage. I. Factors causing the pathologic deposition of colloidal carbon.胶体物质在血管内皮中的定位：一种组织损伤机制。I. 导致胶体碳病理性沉积的因素
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The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice.伤寒杆菌及其内毒素对小鼠网状内皮系统吞噬活性的影响。
Br J Exp Pathol. 1955 Jun;36(3):226-35.
6
The glomerular mesangium. II. Studies of macromolecular uptake in nephrotoxic nephritis in rats.肾小球系膜。II. 大鼠肾毒性肾炎中大分子摄取的研究。
J Clin Invest. 1974 Feb;53(2):431-9. doi: 10.1172/JCI107577.
7
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Evidence concerning the origin of liver macrophages.关于肝巨噬细胞起源的证据。
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The ultrastructure of the juxtaglomerular apparatus as disclosed by three-dimensional reconstructions from serial sections. The anatomical relationship between the tubular and vascular components.通过连续切片的三维重建所揭示的球旁器超微结构。肾小管和血管成分之间的解剖关系。
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