Shvil Y, Mauer S M, Michael A F
Br J Exp Pathol. 1980 Feb;61(1):30-8.
The uptake of radiolabelled (125I) aggregated human IgG (AggIgG) by the renal cortex, liver, spleen and lung was evaluated quantitatively in mice treated with hydrocortisone (HC) (25 mg) 72 h previously. AggIgG was administered in a dose of 1.5 or 3.5 mg/g body wt i.v.; tissue and blood were obtained at 1, 4 and 24 h. Renal cortical and mesangial uptake of AggIgG was significantly increased in HC animals. A rise in blood level was also observed in association with decreased splenic uptake, normal or slightly increased hepatic uptake and unchanged lung uptake. A significant increase in the kidney:lung and kidney:spleen ratios of AggIgG was induced by hydrocortisone, suggesting a relatively greater rate of loss from the spleen and liver than the renal cortex. The increased mesangial uptake may be a consequence of higher blood levels of AggIgG, as well as a direct effect of HC on the mesangium.
在72小时前用氢化可的松（HC）（25毫克）处理过的小鼠中，对肾皮质、肝脏、脾脏和肺摄取放射性标记（125I）的人聚合免疫球蛋白（AggIgG）进行了定量评估。AggIgG以1.5或3.5毫克/克体重的剂量静脉注射；在1小时、4小时和24小时采集组织和血液。HC处理的动物中，AggIgG在肾皮质和系膜的摄取显著增加。还观察到血液水平升高，同时脾脏摄取减少，肝脏摄取正常或略有增加，肺摄取无变化。氢化可的松导致AggIgG的肾:肺和肾:脾比率显著增加，这表明与肾皮质相比，脾脏和肝脏的丢失率相对更高。系膜摄取增加可能是AggIgG血液水平升高的结果，也是HC对系膜的直接作用。
