[Conditions influencing bone induction after implantation of the bone matrix into mice].

In the course of implanting a decalcified bone matrix to mice intramuscularly, beneath the renal capsule and the capsule of the kidney with ligated vessels, and intramuscularly to animals with curretaged femur, bone induction was evoked in 90--100% of the cases, with no morphological differences recorded. In each series of the experiments both implants with marked bone plates full of bone marrow cells and implants with small areas of osteogenic tissue were observed. The data obtained show that the inductive process does not depend either on the degree of vascularization of the site of implantation or on the degree of calcification of adjacent tissue and may be predetermined by the presence of inducible cells sensitive to the induction stimulus.