Raevskaia M V
Biull Eksp Biol Med. 1980;89(1):45-6.
In the course of implanting a decalcified bone matrix to mice intramuscularly, beneath the renal capsule and the capsule of the kidney with ligated vessels, and intramuscularly to animals with curretaged femur, bone induction was evoked in 90--100% of the cases, with no morphological differences recorded. In each series of the experiments both implants with marked bone plates full of bone marrow cells and implants with small areas of osteogenic tissue were observed. The data obtained show that the inductive process does not depend either on the degree of vascularization of the site of implantation or on the degree of calcification of adjacent tissue and may be predetermined by the presence of inducible cells sensitive to the induction stimulus.
在将脱钙骨基质肌肉内植入小鼠、结扎血管后植入肾被膜下和肾包膜内以及刮除股骨后的动物肌肉内的过程中，90%-100%的病例诱发了骨诱导，未记录到形态学差异。在每组实验中，均观察到充满骨髓细胞的明显骨板植入物和小面积成骨组织植入物。所得数据表明，诱导过程既不取决于植入部位的血管化程度，也不取决于相邻组织的钙化程度，可能由对诱导刺激敏感的诱导细胞的存在预先决定。
