Bancroft J, Davidson D W, Warner P, Tyrer G
Clin Endocrinol (Oxf). 1980 Apr;12(4):327-40. doi: 10.1111/j.1365-2265.1980.tb02718.x.
Twenty women using oral contraceptives and complaining of impaired sexual function were compared with twenty women without sexual problems, matched for age and oral contraceptive. Whilst the sexual behaviour differed in the two groups, the plasma testosterone, androstenedione, oestradiol and SHBG concentrations were very similar. The total androgen levels were low in both groups. Plasma testosterone and oestradiol concentrations were correlated with measures of sexual interest in the no-problem group, but not in the problem group. Administration of exogenous androstenedione to women in the problem group, using a double blind cross-over comparison with a placebo, failed to improve their sexual function except in one case. The majority of women showed a rise in androgen and oestradiol between day 24 of one pill cycle and day 4 of the next. The possible behavioural indications of this pattern are discussed.
对20名使用口服避孕药并抱怨性功能受损的女性与20名无性功能问题的女性进行了比较，两组在年龄和口服避孕药使用情况上相匹配。虽然两组的性行为存在差异，但血浆睾酮、雄烯二酮、雌二醇和性激素结合球蛋白（SHBG）的浓度非常相似。两组的总雄激素水平都较低。在无问题组中，血浆睾酮和雌二醇浓度与性兴趣指标相关，但在有问题组中则不然。在有问题组的女性中使用外源性雄烯二酮，并与安慰剂进行双盲交叉比较，结果除1例之外未能改善她们的性功能。大多数女性在一个服药周期的第24天到下一个周期的第4天之间雄激素和雌二醇有所升高。本文讨论了这种模式可能的行为指征。
