Failure of suppression of intrarenal angiotensin II in the contralateral kidney of one-clip two-kidney hypertensive rats.

1. Two-kidney one-clip hypertension was produced in rats by application of a 0.20 mm clip to the left renal artery. 2. After three weeks, the animals had mildly elevated PRA, kidney renin was elevated in the clipped kidney and markedly suppressed in the contralateral kidney when compared to values in sham-operated rats. 3. Intrarenal AII was elevated in the clipped kidney either when compared to the contralateral kidney or to values in the controls. However, in the contralateral kidney, AII was not different from controls. 4. Changes in intrarenal AII do not, therefore, always parallel those of renal renin. Failure of suppression of AII in the contralateral kidney is likely to be of pathogenetic importance in development of hypertension in this experimental model.