集合管肾素：血管紧张素II依赖性高血压的主要参与者。
Collecting Duct Renin: A major player in Angiotensin II-dependent Hypertension.
作者信息
Prieto-Carrasquero Minolfa C, Botros Fady T, Kobori Hiroyuki, Navar L Gabriel
机构信息
Department of Physiology and Tulane Renal Hypertension Center, Tulane University, School of Medicine, New Orleans, LA, 70112.
出版信息
J Am Soc Hypertens. 2009 Mar-Apr;3(2):96-104. doi: 10.1016/j.jash.2008.11.003.
Abstract
Recently, the focus of interest on the role of the renin angiotensin system in the pathophysiology of hypertension has shifted towards greater emphasis on new developments in local renin angiotensin systems in specific tissues. We have focused our recent investigations on the role of the intrarenal-intratubular RAS in hypertension. All of the components needed for angiotensin II generation are present within the various compartments in the kidney. This brief review is focused on recent evidence that inappropriate activation of renin in distal nephron segments, by acting on angiotensinogen generated in the proximal tubule cells and delivered to the distal nephron may contribute to increased distal intrarenal angiotensin II formation, sodium retention and development and progression of hypertension.
摘要
最近，肾素血管紧张素系统在高血压病理生理学中作用的研究重点已转向更加强调特定组织中局部肾素血管紧张素系统的新进展。我们最近的研究集中在肾内肾小管内肾素血管紧张素系统在高血压中的作用。肾内生成血管紧张素II所需的所有成分都存在于肾脏的各个腔室中。本简要综述聚焦于近期的证据，即远端肾单位节段中肾素的不适当激活，通过作用于近端小管细胞产生并输送至远端肾单位的血管紧张素原，可能导致远端肾内血管紧张素II生成增加、钠潴留以及高血压的发生和进展。
相似文献
1
Collecting Duct Renin: A major player in Angiotensin II-dependent Hypertension.集合管肾素：血管紧张素II依赖性高血压的主要参与者。
J Am Soc Hypertens. 2009 Mar-Apr;3(2):96-104. doi: 10.1016/j.jash.2008.11.003.
2
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.肾内肾素-血管紧张素系统：从生理学到高血压和肾脏疾病的病理生物学
Pharmacol Rev. 2007 Sep;59(3):251-87. doi: 10.1124/pr.59.3.3.
3
Role of stimulated intrarenal angiotensinogen in hypertension.刺激肾内血管紧张素原在高血压中的作用。
Ther Adv Cardiovasc Dis. 2015 Aug;9(4):181-90. doi: 10.1177/1753944715585512. Epub 2015 May 18.
4
(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice.（前）肾素受体阻断可防止2K1C Goldblatt小鼠肾脏中收缩压升高、钠潴留及αENaC蛋白表达增加。
Int J Mol Sci. 2025 Apr 28;26(9):4177. doi: 10.3390/ijms26094177.
5
Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review.集合管肾素和（前）肾素受体在高血压中的作用：综述
Ther Adv Cardiovasc Dis. 2015 Aug;9(4):191-200. doi: 10.1177/1753944715574817. Epub 2015 Mar 16.
6
Evolving concepts on regulation and function of renin in distal nephron.远端肾单位中肾素调节和功能的不断发展的概念。
Pflugers Arch. 2013 Jan;465(1):121-32. doi: 10.1007/s00424-012-1151-6. Epub 2012 Sep 19.
7
Role of Collecting Duct Renin in the Pathogenesis of Hypertension.集合管肾素在高血压发病机制中的作用。
Curr Hypertens Rep. 2017 Aug;19(8):62. doi: 10.1007/s11906-017-0763-9.
8
Translational studies on augmentation of intratubular renin-angiotensin system in hypertension.高血压患者肾小管内肾素-血管紧张素系统增强的转化研究。
Kidney Int Suppl (2011). 2013 Dec;3(4):321-325. doi: 10.1038/kisup.2013.67.
9
Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension.血管紧张素II依赖性高血压中近端肾小管肾素-血管紧张素系统的最新进展
Curr Hypertens Rep. 2016 Aug;18(8):63. doi: 10.1007/s11906-016-0668-z.
10
Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats.在二肾一夹型Goldblatt高血压大鼠的双侧肾脏中，集合管肾素上调。
Hypertension. 2008 Jun;51(6):1590-6. doi: 10.1161/HYPERTENSIONAHA.108.110916. Epub 2008 Apr 21.
引用本文的文献
1
Collecting Duct Pro(Renin) Receptor Contributes to Unilateral Ureteral Obstruction-Induced Kidney Injury via Activation of the Intrarenal RAS.收集管 Pro（血管紧张素原）受体通过激活肾内 RAS 促进单侧输尿管梗阻诱导的肾脏损伤。
Hypertension. 2024 Oct;81(10):2152-2161. doi: 10.1161/HYPERTENSIONAHA.123.21740. Epub 2024 Aug 22.
2
Polycystic kidneys: interaction of notch and renin.多囊肾病： Notch 与肾素的相互作用。
Clin Sci (Lond). 2023 Aug 14;137(15):1145-1150. doi: 10.1042/CS20230023.
3
Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct.激素对集合管中肾素的调节及对前肾素受体信号的影响。
Curr Hypertens Rev. 2022;18(2):91-100. doi: 10.2174/1573402118666220216105357.
4
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.miR-181a 缺失导致肾脏转录组细胞特异性变化，并增加血压。
Hypertension. 2021 Nov;78(5):1322-1334. doi: 10.1161/HYPERTENSIONAHA.121.17384. Epub 2021 Sep 20.
5
Patterns of differentiation of renin lineage cells during nephrogenesis.肾素谱系细胞在肾发生过程中的分化模式。
Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F378-F388. doi: 10.1152/ajprenal.00151.2021. Epub 2021 Aug 2.
6
High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct.高糖诱导原肾素受体的转运，并刺激集合管中的促纤维化因子。
Sci Rep. 2021 Jul 5;11(1):13815. doi: 10.1038/s41598-021-93296-4.
7
Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice.原肾素受体切割位点的突变可消除血管紧张素 II 诱导的小鼠高血压。
Hypertension. 2021 Jul;78(1):115-127. doi: 10.1161/HYPERTENSIONAHA.121.16770. Epub 2021 May 24.
8
Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice.位点 1 蛋白酶衍生的可溶性（前）肾素受体促进小鼠血管紧张素 II 诱导的高血压。
Hypertension. 2021 Feb;77(2):405-416. doi: 10.1161/HYPERTENSIONAHA.120.15100. Epub 2020 Dec 7.
9
COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.COX-2 非依赖性激活肾（前）肾素受体参与大鼠 DOCA-盐高血压的发生。
Am J Physiol Renal Physiol. 2020 Oct 1;319(4):F647-F653. doi: 10.1152/ajprenal.00112.2020. Epub 2020 Aug 17.
10
Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology.肾脏集合管中的闰细胞在肾脏生理学中的作用。
Semin Nephrol. 2019 Jul;39(4):353-367. doi: 10.1016/j.semnephrol.2019.04.005.
本文引用的文献
1
Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice.慢性输注血管紧张素II的小鼠肾内血管紧张素II和血管紧张素原增加。
Am J Physiol Renal Physiol. 2008 Sep;295(3):F772-9. doi: 10.1152/ajprenal.00019.2008. Epub 2008 Jun 25.
2
Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats.在二肾一夹型Goldblatt高血压大鼠的双侧肾脏中，集合管肾素上调。
Hypertension. 2008 Jun;51(6):1590-6. doi: 10.1161/HYPERTENSIONAHA.108.110916. Epub 2008 Apr 21.
3
The collecting duct is the major source of prorenin in diabetes.集合管是糖尿病中肾素原的主要来源。
Hypertension. 2008 Jun;51(6):1597-604. doi: 10.1161/HYPERTENSIONAHA.107.107268. Epub 2008 Apr 14.
4
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway.血管紧张素II上调血管紧张素I转换酶（ACE），但通过AT1-ERK/p38丝裂原活化蛋白激酶途径下调ACE2。
Am J Pathol. 2008 May;172(5):1174-83. doi: 10.2353/ajpath.2008.070762. Epub 2008 Apr 10.
5
Critical review of prorenin and (pro)renin receptor research.肾素原及（前）肾素受体研究的批判性综述。
Hypertension. 2008 May;51(5):1259-64. doi: 10.1161/HYPERTENSIONAHA.108.110924. Epub 2008 Mar 17.
6
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats.（前）肾素受体肽抑制剂“柄区”肽不影响戈德布拉特大鼠的高血压性肾硬化。
Hypertension. 2008 Mar;51(3):676-81. doi: 10.1161/HYPERTENSIONAHA.107.101493. Epub 2008 Jan 22.
7
Expression of angiotensin I-converting enzymes and bradykinin B2 receptors in mouse inner medullary-collecting duct cells.血管紧张素I转换酶和缓激肽B2受体在小鼠髓质集合管细胞中的表达
Int Immunopharmacol. 2008 Feb;8(2):254-60. doi: 10.1016/j.intimp.2007.09.013. Epub 2007 Oct 9.
8
Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats.抗高血压治疗上调戈德布拉特高血压大鼠夹闭肾脏中的肾素和（前）肾素受体。
Kidney Int. 2007 Sep;72(6):725-30. doi: 10.1038/sj.ki.5002408. Epub 2007 Jun 27.
9
Increased cyclooxygenase-2, hyperfiltration, glomerulosclerosis, and diabetic nephropathy: put the blame on the (pro)renin receptor?环氧化酶-2增加、超滤、肾小球硬化与糖尿病肾病：将责任归咎于（前）肾素受体？
Kidney Int. 2006 Aug;70(4):618-20. doi: 10.1038/sj.ki.5001723.
10
Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat.雄性同源mRen2. Lewis大鼠肾脏中核血管紧张素II 1型受体的差异表达
Am J Physiol Renal Physiol. 2006 Jun;290(6):F1497-506. doi: 10.1152/ajprenal.00317.2005. Epub 2006 Jan 10.
Zotero 插件