Thoenes G H, Pielsticker K, Schreiber M A
Clin Nephrol. 1980 Mar;13(3):133-41.
The correlation between the degree of histoincompatibility and kidney graft survival after active sensitization by blood transfusions has been investigated in congenic resistant strains of rats with MHC (H-1)-restricted incompatibility as compared to standard strains. It has been found that the beneficial effect of transfusions for graft survival becomes most evident when compatibility for the so-called minor non-H-1-antigens exists. H-1-congenic rats with MHC differences alone show indefinite graft survival irrespective of the interallelic combination. Donor-specific sensitization is the treatment of choice. Third-party blood is by far inferior. H-1-identical, but non-H-1-different blood, with respect to the recipient strain genotype, is ineffective in the facilitation of H-1-different grafts. The facilitation effect does not increase with the number of blood injections. As early as 1 week after blood treatment, there is permanent survival of grafted kidneys, but there is a definite loss of graft-protecting factors with time.
通过输血进行主动致敏后，组织不相容程度与肾移植存活之间的相关性已在具有MHC（H-1）限制性不相容的同基因抗性大鼠品系中进行了研究，并与标准品系进行了比较。已发现，当存在所谓的次要非H-1抗原相容性时，输血对移植存活的有益作用最为明显。仅具有MHC差异的H-1同基因大鼠显示出不确定的移植存活，而与等位基因组合无关。供体特异性致敏是首选治疗方法。第三方血液远远不如供体特异性致敏。就受体品系基因型而言，H-1相同但非H-1不同的血液在促进H-1不同的移植方面无效。促进作用不会随着输血次数的增加而增强。早在输血治疗后1周，移植的肾脏就会永久存活，但随着时间的推移，移植保护因子会有一定程度的丧失。
