Kaden J, Oesterwitz H, Groth J
Allerg Immunol (Leipz). 1986;32(3):143-51.
At different intervals (2, 4, 8, 12 and 21 days) after preimmunization of BD IX inbred rats with density gradient-separated nylon-wool-adherent spleen lymphocytes from rats of the MHC different inbred strain Sprague-Dawley, (BD IX X SD)F1 kidneys were transplanted into the immunized BD IX rats. The non-immunized control rats died after 11-16 days. Kidneys transplanted 8 or 12 days after preimmunization survived indefinitely without any signs of rejection. In contrast, the rats grafted 2 and 4 days after preimmunization showed elevated levels of blood urea nitrogen (mean: 70-83 mmol/l) on the 7th post-operative day. The transplantation on day 21 resulted in a slight rejection episode on the 7th postoperative day. These results suggest the efficacy of nylon-wool-adherent lymphocytes in inducing an active transplant protection.
用密度梯度分离的来自MHC不同近交系大鼠斯普拉格 - 道利（Sprague-Dawley）的尼龙毛黏附脾淋巴细胞对BD IX近交系大鼠进行预免疫后，在不同时间间隔（2、4、8、12和21天），将（BD IX×SD）F1代大鼠的肾脏移植到免疫后的BD IX大鼠体内。未免疫的对照大鼠在11 - 16天后死亡。预免疫8或12天后移植的肾脏可无限期存活，无任何排斥迹象。相比之下，预免疫2天和4天后移植的大鼠在术后第7天血尿素氮水平升高（平均：70 - 83 mmol/L）。在第21天进行的移植在术后第7天导致了轻微的排斥反应。这些结果表明尼龙毛黏附淋巴细胞在诱导主动移植保护方面的有效性。
