Studer A, Záruba K, Grimm J, Kuhlmann U, Siegenthaler W, Vetter W
Clin Nephrol. 1980 Apr;13(4):172-6.
To investigate the effect of chronic hemodialysis (CH) on adrenal aldosterone release plasma aldosterone (PA), plasma renin activity (PRA), plasma cortisol (PC) and the serum concentrations of potassium (K) and sodium (Na) were measured before and at monthly intervals up to 26 months after initiation of CH in 42 patients with terminal renal failure. Body weight (BW), systolic (BPs) and diastolic (BPd) blood pressure were determined simultaneously. With 2 exceptions PA, PRA and PC as well as BW, BPs and BPd showed no significant changes. Following month 2 K was always significantly higher than the starting value while significantly higher Na values were observed in 12 of 26 different test periods (P less than 0.05--less than 0.001). Correlation analysis between the various parameters determined in this study revealed in 16 of 26 different months a significant relationship between PA and PRA (P less than 0.05--less than 0.001) and as expected in 20 of 26 between BPs and BPd (P less than 0.05--less than 0.001). Only at times were punctual correlations seen between any of the remaining parameters. Our results demonstrate that the prime influence of the renin angiotensin system on PA remains unaltered during CH. We conclude that the observed punctual correlations between the various parameters determined in this study are random and do not reflect a true relationship.
为研究慢性血液透析（CH）对肾上腺醛固酮释放的影响，对42例终末期肾衰竭患者在开始CH之前及开始后每月测定一次血浆醛固酮（PA）、血浆肾素活性（PRA）、血浆皮质醇（PC）以及血清钾（K）和钠（Na）的浓度，同时测定体重（BW）、收缩压（BPs）和舒张压（BPd）。除2例例外，PA、PRA、PC以及BW、BPs和BPd均无显著变化。第2个月后，K始终显著高于起始值，而在26个不同测试期的12个中观察到Na值显著升高（P小于0.05至小于0.001）。本研究测定的各项参数之间的相关性分析显示，在26个不同月份中的16个，PA与PRA之间存在显著关系（P小于0.05至小于0.001），正如预期的那样，在26个中的20个，BPs与BPd之间存在显著关系（P小于0.05至小于0.001）。仅在某些时候，其余参数之间存在即时相关性。我们的结果表明，肾素-血管紧张素系统对PA的主要影响在CH期间保持不变。我们得出结论，本研究中测定的各项参数之间观察到的即时相关性是随机的，并不反映真实关系。
