Louis F, Zwahlen A, Favre H, Vallotton M
Schweiz Med Wochenschr. 1980 Dec 6;110(49):1882-4.
The role of potassium in regulating plasma aldosterone has been studied in 7 patients with end-stage renal disease undergoing hemodialysis. Plasma renin activity (PRA), plasma aldosterone, cortisol, sodium and potassium, and total potassium loss were measured before and after two sessions of dialysis in each patient. The only difference between the two sessions was the potassium content of the dialysate (4 mmol/l versus l mmol/l). Plasma potassium, potassium pool and plasma aldosterone decreased significantly when the patients were dialyzed with a l mmol/l K bath. In contrast, the same parameters remained unchanged when the patients were dialyzed with a 4 mmol/l K bath. Irrespective of the dialysate used, there were no differences either in changes in body weight and PRA, or in plasma sodium and cortisol levels, before and after dialysis. In conclusion, in patients with end-stage renal disease, potassium predominates over PRA and volume depletion in the regulation of plasma aldosterone.
在7例接受血液透析的终末期肾病患者中研究了钾在调节血浆醛固酮中的作用。在每位患者进行两次透析前后，测量血浆肾素活性（PRA）、血浆醛固酮、皮质醇、钠和钾以及总钾丢失量。两次透析之间的唯一区别是透析液中的钾含量（4 mmol/L对1 mmol/L）。当患者使用1 mmol/L钾浴进行透析时，血浆钾、钾池和血浆醛固酮显著降低。相比之下，当患者使用4 mmol/L钾浴进行透析时，相同参数保持不变。无论使用何种透析液，透析前后体重和PRA的变化以及血浆钠和皮质醇水平均无差异。总之，在终末期肾病患者中，在调节血浆醛固酮方面，钾比PRA和容量耗竭起更主要作用。
