Nishizawa M, Okada T, Sato F, Kariya A, Mayama S, Nakamura K
Endoscopy. 1980 May;12(3):124-9. doi: 10.1055/s-2007-1021727.
Magnifying fiber-colonoscopy reveals that adenoma, minute carcinomatous lesion in an adenoma (which is termed focal carcinoma), and mucosal carcinoma of the colon, each has its own characteristic pit pattern. Inspection by dissecting microscope of resected specimens obtained from subjects whose colonic mucosa had been considered normal, often reveals an abnormal pit pattern of less than 1 mm, and subsequent histologic examination confirms the frequent presence of incipient adenoma. Clinical magnification inspection of areas of colonic mucosa considered normal on the basis of ordinary observation, reveals pit patterns identical to those seen in resected specimens.
放大电子结肠镜检查显示，腺瘤、腺瘤内微小癌性病变（称为局灶癌）以及结肠黏膜癌，各自都有其独特的凹陷形态。对结肠黏膜被认为正常的受试者切除标本进行解剖显微镜检查，常可发现小于1毫米的异常凹陷形态，随后的组织学检查证实早期腺瘤很常见。对基于普通观察认为正常的结肠黏膜区域进行临床放大检查，发现的凹陷形态与切除标本中所见相同。
