Lammintausta R
Int J Clin Pharmacol Ther Toxicol. 1980 Mar;18(3):110-12.
In the clinical evaluation of renin status, the effect of chronic digitalization is unknown. A 50 per cent decrease in PRA is presented after intravenous digoxin injection. In this study the acute intake of 0.75 mg digoxin decreased PRA slightly (p less than 0,05), but no difference could be found in ten healthy volunteers in regard to PRA after placebo, randomly examined twice after digoxin and once after placebo tablets. Eight healthy volunteers were digitalized with 2.5 mg digoxin in total during four days. Renin release was stimulated by ergometric exercise (900 kpm for 10 min) before and after digitalization, when the mean serum digoxin concentration was 2.0 +/- 0.2 ng/ml (SEM). No difference in basal or exercise-stimulated PRA could be found after digoxin. We conclude that the steady state digitalis therapy does not interfere with renin release. The peripheral vasoconstriction accompanied with the acute intravenous digitalis administration can lead to a transient decrease of PRA.
在对肾素状态的临床评估中，长期使用洋地黄的影响尚不清楚。静脉注射地高辛后，血浆肾素活性（PRA）下降了50%。在本研究中，0.75毫克地高辛的急性摄入量使PRA略有下降（p<0.05），但在10名健康志愿者中，服用安慰剂后、随机服用地高辛两次后及服用安慰剂片一次后，在PRA方面未发现差异。8名健康志愿者在4天内总共服用了2.5毫克地高辛进行洋地黄化。在洋地黄化前后，当平均血清地高辛浓度为2.0±0.2纳克/毫升（标准误）时，通过测力运动（900千帕米，持续10分钟）刺激肾素释放。服用地高辛后，基础或运动刺激的PRA均未发现差异。我们得出结论，稳态洋地黄治疗不会干扰肾素释放。急性静脉注射洋地黄伴随的外周血管收缩可导致PRA短暂下降。
