Gharib C, Vincent M, Annat G, Allevard A M, Geelen G, Geyssant A, Eclache J P, Lacour R, Bizollon C A
J Physiol (Paris). 1981 Mar;77(8):911-4.
The effect of training on PRA, PA, hematocrit and weight loss was studied at rest and following an exercise performed until exhaustion. Two groups of subjects were used, the first, a group of 4 young well trained men (88.6% +/- 7.7 V02 max) and the second a group of 4 young untrained men (77.5% +/- 7 V02 max). PRA and PA displayed highly significant increases after exercise in both groups, but PRA resting values were lower in the well trained subjects (p less than 0.05). PRA values were also lower in the latter group after exercise, but the difference in this case was not significant. Further, the variation of hematocrit was less (p less than 0.05) and the weight loss greater in the well trained subjects. In an additional experiment, the same parameters were studied in four subjects submitted to a five month training programme (87% V02 max). Though resting values for PA remained unchanged after training, PRA resting values and PRA post exercise values were significantly lower. A comparison between the magnitude of weight loss and hematocrit variation showed that when untrained subjects became trained, the variation of hematocrit was smaller (p less than 0.05) while weight loss was larger (p less than 0.01). These observations could be explained in terms of the change in blood volume, and/or a decrease in sympathetic nervous activity induced by training.
研究了训练对肾素活性(PRA)、醛固酮(PA)、血细胞比容和体重减轻的影响,测试了静息状态以及运动至力竭后的情况。实验使用了两组受试者,第一组是4名训练有素的年轻男性(最大摄氧量为88.6%±7.7),第二组是4名未经训练的年轻男性(最大摄氧量为77.5%±7)。两组运动后PRA和PA均显著升高,但训练有素的受试者静息时的PRA值较低(p<0.05)。后一组运动后的PRA值也较低,但这种差异不显著。此外,训练有素的受试者血细胞比容变化较小(p<0.05),体重减轻较多。在另一项实验中,对4名接受了五个月训练计划(最大摄氧量为87%)的受试者进行了相同参数的研究。尽管训练后PA的静息值保持不变,但PRA的静息值和运动后PRA值显著降低。体重减轻幅度与血细胞比容变化的比较表明,未经训练的受试者经过训练后,血细胞比容变化较小(p<0.05),而体重减轻较大(p<0.01)。这些观察结果可以用血容量的变化和/或训练引起的交感神经活动减少来解释。