Browett P J, Simpson L O, Blennerhassett J B
J Pathol. 1980 Jan;130(1):57-64. doi: 10.1002/path.1711300108.
Bentonite, a silicate, induces a classical non-immunological foreign body reaction when injected intradermally into guinea pigs. The cellular response consists of a mass of macrophages and large macrophage polykaryons, surrounded and infiltrated by an extensive fibrous reaction. The bentonite granuloma shows no signs of intercellular organisation of the reacting cells. Study of its ultrastructure suggests a low turnover lesion with a stable, long-lived cell population. The bentonite granuloma is contrasted with the tuberculous, immunologically mediated epithelioid cell granuloma produced in sensitised guinea pigs.
膨润土是一种硅酸盐，将其皮内注射到豚鼠体内时会引发典型的非免疫性异物反应。细胞反应由大量巨噬细胞和大型巨噬细胞多核体组成，周围伴有广泛的纤维反应并被其浸润。膨润土肉芽肿未显示出反应细胞的细胞间组织迹象。对其超微结构的研究表明，这是一种细胞更新率低的病变，细胞群体稳定且寿命长。膨润土肉芽肿与致敏豚鼠产生的免疫介导的结核性上皮样细胞肉芽肿形成对比。
