Erokhin V V
Arkh Patol. 1978;40(6):37-44.
In the process of histogenesis of tuberculosis granuloma in which the leading role belongs to cells of the bone-marrow origin their initial ultrastructure is rearranged and forms characterized by a high functional activity emerge. Mononuclear cells are transformed both into macrophages and epithelioid cells. Ultrastructural and functional differences in epithelioid cells were found. Some of them synthesize mainly hydrolytic enzymes, others protein, still others apparently produce glycosaminoglycans. The former have functions of macrophages, in the others no signs of phagocytosis are observed. Complexes of contacting epithelioid cells are one of the sources of multinuclear giant cells.
在结核性肉芽肿的组织发生过程中，骨髓来源的细胞起主要作用，其初始超微结构发生重排，并出现具有高功能活性的形态特征。单核细胞可转化为巨噬细胞和上皮样细胞。发现上皮样细胞存在超微结构和功能差异。其中一些主要合成水解酶，另一些合成蛋白质，还有一些显然产生糖胺聚糖。前者具有巨噬细胞的功能，而在后者中未观察到吞噬作用的迹象。相互接触的上皮样细胞复合体是多核巨细胞的来源之一。
