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S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents.

作者信息

Borchardt R T

出版信息

J Med Chem. 1980 Apr;23(4):347-57. doi: 10.1021/jm00178a001.

DOI:10.1021/jm00178a001
PMID:6991690
Abstract
摘要

相似文献

1
S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents.S-腺苷-L-甲硫氨酸依赖性大分子甲基转移酶：化疗药物设计的潜在靶点。
J Med Chem. 1980 Apr;23(4):347-57. doi: 10.1021/jm00178a001.
2
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。6. S-腺苷甲硫氨酸的结构修饰。
J Med Chem. 1976 Sep;19(9):1104-10. doi: 10.1021/jm00231a005.
3
Inhibitors of tRNA methyltransferases. S-Adenosylsulfonium salts.转运RNA甲基转移酶抑制剂。S-腺苷锍盐。
J Med Chem. 1976 Oct;19(10):1191-5. doi: 10.1021/jm00232a005.
4
Synthesis and evaluation of analogues of S-adenosyl-L-methionine, as inhibitors of the E. coli cyclopropane fatty acid synthase.S-腺苷-L-甲硫氨酸类似物作为大肠杆菌环丙烷脂肪酸合酶抑制剂的合成与评价
Bioorg Med Chem Lett. 2004 Apr 5;14(7):1661-4. doi: 10.1016/j.bmcl.2004.01.051.
5
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 7. Role of the ribosyl moiety in enzymatic binding of S-adenosyl-L-homocysteine and S-adenosyl-L-methionine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。7. 核糖基部分在S-腺苷-L-高半胱氨酸和S-腺苷-L-甲硫氨酸酶促结合中的作用。
J Med Chem. 1978 Dec;21(12):1307-10. doi: 10.1021/jm00210a026.
6
The activity of adenosyl-D-methionine and adenosyl-2-methylmethionine in transmethylations.腺苷-D-甲硫氨酸和腺苷-2-甲基甲硫氨酸在转甲基作用中的活性。
Arch Biochem Biophys. 1976 Nov;177(1):170-5. doi: 10.1016/0003-9861(76)90426-4.
7
Comparative studies on S-adenosyl-L-methionine binding sites of protein N-methyltransferases, using 8-azido-S-adenosyl-L-methionine as photoaffinity probe.以8-叠氮基-S-腺苷-L-甲硫氨酸作为光亲和探针，对蛋白质N-甲基转移酶的S-腺苷-L-甲硫氨酸结合位点进行的比较研究。
J Protein Chem. 1993 Oct;12(5):603-12. doi: 10.1007/BF01025125.
8
Metabolism of S-adenosylmethionine in rat hepatocytes: transfer of methyl group from S-adenosylmethionine by methyltransferase reactions.大鼠肝细胞中S-腺苷甲硫氨酸的代谢：通过甲基转移酶反应从S-腺苷甲硫氨酸转移甲基基团。
Life Sci. 1985 Aug 19;37(7):665-72. doi: 10.1016/0024-3205(85)90434-5.
9
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 5. Role of the asymmetric sulfonium pole in the enzymatic binding of S-adenosyl-L-methionine.S-腺苷甲硫氨酸依赖性甲基转移酶的潜在抑制剂。5. 不对称锍极在S-腺苷-L-甲硫氨酸酶促结合中的作用。
J Med Chem. 1976 Sep;19(9):1099-1103. doi: 10.1021/jm00231a004.
10
[New studies on inhibition of tRNA N2 guanine methyltransferase by S-adenosyl-homocysteine and S-adenosyl-methionine analogs].[S-腺苷同型半胱氨酸和S-腺苷甲硫氨酸类似物对tRNA N2鸟嘌呤甲基转移酶抑制作用的新研究]
Biochimie. 1976;58(1-2):201-5. doi: 10.1016/s0300-9084(76)80370-7.

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The Epstein-Barr virus EBNA1 protein binds to G-quadruplexes in its own mRNA hence controlling its expression and immune evasion of the virus.爱泼斯坦-巴尔病毒EBNA1蛋白与其自身mRNA中的G-四链体结合，从而控制病毒的表达和免疫逃逸。
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I 型精氨酸甲基转移酶是揭示致癌性 Epstein-Barr 病毒的免疫干预点。
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Direct Detection of Products from S-Adenosylmethionine-Dependent Enzymes Using a Competitive Fluorescence Polarization Assay.使用竞争荧光偏振测定法直接检测 S-腺苷甲硫氨酸依赖性酶的产物。
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