Lipton J M, Nathan D G
Pediatr Clin North Am. 1980 May;27(2):217-35. doi: 10.1016/s0031-3955(16)33848-2.
Aplastic anemia is an acquired or constitutional trilineage bone marrow failure with peripheral pancytopenia, evidence of cellular hypoplasia of marrow, and replacement of normal cellular elements by fat. In some cases the marrow may be hypoplastic and the peripheral cytopenia relatively mild. The condition may persist for years and result in acute leukemia. In other cases, hypoplasia may involve only a single cell line. Basic research is directed toward understanding the multitude of cells, with a view toward selective manipulation of the cells themselves, interacting hormones, or cellular regulators. Early bone marrow transplantation presently offers the most hope when compatible donors are available.
再生障碍性贫血是一种获得性或先天性的三系骨髓衰竭，伴有外周全血细胞减少、骨髓细胞发育不全的证据以及正常细胞成分被脂肪替代。在某些情况下，骨髓可能发育不全，外周血细胞减少相对较轻。这种情况可能持续数年并导致急性白血病。在其他情况下，发育不全可能仅涉及单一细胞系。基础研究旨在了解众多细胞，以期对细胞本身、相互作用的激素或细胞调节因子进行选择性调控。当有合适的供体时，早期骨髓移植目前提供了最大的希望。
