Pouplard A, Bigorgne J C, Chevalier J M, Rohmer V, Poron M F
Nouv Presse Med. 1980 Jun 7;9(25):1757-60.
An indirect immunofluorescence study of the serum of 37 patients with anterior pituitary disease suggested that in a number of them an auto-immune process intervened in the pathogenesis of the condition. Seven sera reacted positively to human pituitary gland and 15 to rat pituitary gland. Auto-antibodies directed specifically against one or several types of pituitary cells seem to be more frequent in pituitary insufficiencies involving one or two hormones. These are more readily detectable when rat pituitary glands are used, and only by this technique can auto-antibodies directed against ACTH-secreting cells be detected.
对37例垂体前叶疾病患者血清进行的间接免疫荧光研究表明，其中一些患者的病情发病机制涉及自身免疫过程。7份血清对人垂体呈阳性反应，15份对大鼠垂体呈阳性反应。在涉及一种或两种激素的垂体功能不全患者中，特异性针对一种或几种垂体细胞类型的自身抗体似乎更为常见。当使用大鼠垂体时，这些自身抗体更容易检测到，而且只有通过这种技术才能检测到针对促肾上腺皮质激素分泌细胞的自身抗体。
