Kobayashi I, Shimizu K, Kuwabara A, Fukumura Y
Department of Laboratory Medicine, Gunma University School of Medicine, Maebashi.
Rinsho Byori. 1993 Feb;41(2):123-7.
Amino et al. postulated a postpartum autoimmune thyroid syndrome and Sugiura et al. established an assay for detecting antibodies to anterior pituitary cell surface membrane (PCSA) by immunofluorescent methods. Using this technique, we attempted to determine the prevalence of PCSA before and after delivery. Studies were conducted with 16 pregnant women without any apparent diseases. Serial measurements of PCSA from the sera of each woman before and after delivery were performed by immunofluorescent methods using AtT-20 cells (mouse ACTH secreting cells) and GH3 cells (rat prolactin and GH secreting cells). Antibodies to AtT-20 cells were detected in 5 of 16 pregnant women at 36 weeks (31.3%), while those to GH3 cells were detected in 3 cases (18.8%). Following delivery, positive antibodies were observed in 12 women (75.0%) at 1 month, 15(93.7%) at 3 months and 13 (81.3%) at 6 months. A similar result also was obtained with GH3 cells. It is possible that some of the patients with positive antibodies have functional abnormalities of the anterior pituitary. The results obtained suggest the presence of postpartum autoimmune endocrine syndrome at the anterior pituitary level.
阿米诺等人提出了产后自身免疫性甲状腺综合征，杉浦等人建立了一种通过免疫荧光法检测垂体前叶细胞表面膜（PCSA）抗体的检测方法。利用这项技术，我们试图确定分娩前后PCSA的患病率。对16名无明显疾病的孕妇进行了研究。采用免疫荧光法，使用AtT-20细胞（小鼠促肾上腺皮质激素分泌细胞）和GH3细胞（大鼠催乳素和生长激素分泌细胞），对每位女性分娩前后血清中的PCSA进行连续测量。16名孕妇中，在孕36周时有5例（31.3%）检测到抗AtT-20细胞抗体，3例（18.8%）检测到抗GH3细胞抗体。分娩后，1个月时12名女性（75.0%）、3个月时15名（93.7%）、6个月时13名（81.3%）观察到阳性抗体。GH3细胞也得到了类似的结果。一些抗体阳性的患者可能存在垂体前叶功能异常。所获得的结果提示在垂体前叶水平存在产后自身免疫性内分泌综合征。
