人血浆将前列环素（PGI2）转化为一种能使离体牛冠状动脉收缩的血小板抗聚集物质。

Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries.

作者信息

Gimeno M F, Sterin-Borda L, Borda E S, Lazzari M A, Gimeno A L

出版信息

Prostaglandins. 1980 Jun;19(6):907-16. doi: 10.1016/0090-6980(80)90125-2.

Abstract

Prostacyclin (PGI2) incubated in Human Platelet Rich Plasma (PRP); in Platelet Poor Plasma (PPP) or in Krebs-Ringer-Bicarbonate (KRB) during different periods of time on contractions of bovine coronary arteries and on the ADP platelet aggregative capacity of human PRP, were explored. It was documented that incubates in PRP or in PPP retain an antiaggregatory activity at higher levels and during a longer time than in KRB. On the other hand, PGI2 incubates in KRB exhibited only a relaxing activity on isolated bovine coronary arteries, whereas when incubated in PRP or in PPP presented a biphasic influence. The initial effects (evoked by incubates of 30 minutes) were distinctly relaxing but those obtained with later incubates (60--150 minutes) stimulated clearly the resting basal tone of the arteries. The possibility that the human plasma might have an enzyme(s) able to transform prostacyclin into a more stable material with human antiaggregatory platelet function and bovine coronary contracting capacity is discussed.

摘要

研究了在不同时间段内，将前列环素（PGI2）与人富血小板血浆（PRP）、贫血小板血浆（PPP）或 Krebs-林格碳酸氢盐溶液（KRB）一起孵育，对牛冠状动脉收缩以及人 PRP 的 ADP 诱导血小板聚集能力的影响。结果表明，与在 KRB 中孵育相比，在 PRP 或 PPP 中孵育的前列环素在更高水平和更长时间内保持抗聚集活性。另一方面，PGI2 在 KRB 中孵育时，对离体牛冠状动脉仅表现出舒张活性，而在 PRP 或 PPP 中孵育时则呈现双相影响。最初的影响（由 30 分钟孵育引起）明显是舒张作用，但后期孵育（60 - 150 分钟）所产生的影响则明显刺激了动脉的静息基础张力。文中讨论了人血浆中可能存在某种酶，能够将前列环素转化为具有人血小板抗聚集功能和牛冠状动脉收缩能力的更稳定物质的可能性。