拉贝洛尔与醋丁洛尔单独或联合双肼屈嗪治疗原发性高血压的对比试验。
Comparative trial of labetalol and acebutolol, alone or associated with dihydralazine, in treatment of essential hypertension.
作者信息
Thibonnier M, Lardoux M D, Corvol P
出版信息
Br J Clin Pharmacol. 1980 Jun;9(6):561-7. doi: 10.1111/j.1365-2125.1980.tb01081.x.
Abstract
1 Labetalol, an alpha- and beta- adrenoceptor blocking drug, was compared with acebutolol, alone or associated with dihydralazine in forty patients with moderate essential hypertension. 2 Labetalol (400--800 mg daily) seemed to have a slightly higher potency than acebutolol alone (400--800 mg daily). 3 Labetalol (1200--1600 mg daily) had the same potency as the combination of acebutolol (400--800 mg daily) and dihydralazine (50--100 mg daily). 4 Contrarily to acebutolol, the drop in blood pressure with labetalol was not correlated with initial plasma renin activity. 5 Labetalol side effects were minor and did not lead to drug withdrawal.
摘要
- 将拉贝洛尔（一种α和β肾上腺素能受体阻断药物）与醋丁洛尔单独使用或与双肼屈嗪联合使用，对40例中度原发性高血压患者进行了比较。2. 拉贝洛尔（每日400 - 800毫克）似乎比单独使用醋丁洛尔（每日400 - 800毫克）的效力略高。3. 拉贝洛尔（每日1200 - 1600毫克）与醋丁洛尔（每日400 - 800毫克）和双肼屈嗪（每日50 - 100毫克）联合使用的效力相同。4. 与醋丁洛尔相反，拉贝洛尔引起的血压下降与初始血浆肾素活性无关。5. 拉贝洛尔的副作用较小，未导致停药。
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本文引用的文献
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