普萘洛尔治疗高血压：一项剂量反应研究。
Propranolol in hypertension: a dose-response study.
作者信息
Galloway D B, Glover S C, Hendry W G, Logie A W, Petrie J C, Smith M C, Lewis J A, Simpson W T
出版信息
Br Med J. 1976 Jul 17;2(6028):140-2. doi: 10.1136/bmj.2.6028.140.
The effect of propranolol was studied in a double-blind crossover trial in 24 carefully selected hypertensive outpatients. Each patient received propranolol 60 mg/day, 120 mg/day, 240 mg/day, and placebo for four weeks each according to a randomised sequence. Propranolol 60 mg/day was no better than placebo in reducing blood pressure. The effects of propranolol 120 mg/day and 240 mg/day were not significantly different. Both doses reduced lying blood pressure by about 20/10 mm Hg from an initial level of 173/104 mm Hg. No difference was detected between the effects of the different doses of propranolol and placebo on weight or on the occurrence of adverse reactions.
在一项双盲交叉试验中，对24名精心挑选的高血压门诊患者研究了普萘洛尔的效果。每位患者按照随机顺序，分别接受每日60毫克、120毫克、240毫克的普萘洛尔以及安慰剂治疗，每种治疗持续四周。每日60毫克的普萘洛尔在降低血压方面并不比安慰剂效果更好。每日120毫克和240毫克普萘洛尔的效果无显著差异。两种剂量均使卧位血压从初始水平173/104毫米汞柱降低了约20/10毫米汞柱。不同剂量的普萘洛尔与安慰剂在对体重或不良反应发生情况的影响上未检测到差异。
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