Bamford D S, Jogee M, Williams K I
Br J Obstet Gynaecol. 1980 Mar;87(3):215-8. doi: 10.1111/j.1471-0528.1980.tb04521.x.
Human myometrium taken between 15 and 42 weeks of pregnancy released a material in vitro which possessed anti-aggregatory activity. This material parallelled authentic prostacyclin in this action; it possessed a similar stability at alkaline pH and generation of activity was inhibited by indomethacin. Production of the prostacyclin-like material by the myometrium was similar at weeks 15 and 38 of pregnancy but a 4-fold increase in synthesis had occurred by 40 weeks. It is suggested this increase may be important for parturition.
妊娠15至42周期间获取的人子宫肌层在体外释放出一种具有抗聚集活性的物质。该物质在这一作用方面与天然前列环素相似；它在碱性pH值下具有类似的稳定性，且活性的产生受到吲哚美辛的抑制。子宫肌层产生的类前列环素物质在妊娠15周和38周时相似，但到40周时合成增加了4倍。有人认为这种增加可能对分娩很重要。
