Williams K I, Dembinska-Kieć A, Zmuda A, Gryglewski R J
Prostaglandins. 1978 Feb;15(2):343-50. doi: 10.1016/0090-6980(78)90174-0.
Chopped samples of myometrium, decidua and extrinsic blood vessels from the pregnant rat uterus when incubated at room temperature generated a prostacyclin-like substance. Activity in the incubation mixtures was compared against authentic prostacyclin in two assay systems: relaxation of strips of bovine coronary artery and inhibition of ADP-induced aggregation of rabbit platelet-rich plasma. Results estimated from inhibition of platelet aggregation showed that activity generated by all samples was low on day 12 of pregnancy (less than 0.25 ng/mg). However at the time of delivery (day 22) myometrial synthesis had increased 18.5 fold to over 3 ng/mg of prostacyclin whereas decidual production had only increased 5 times. As there was no increase in synthesis by the extrinsic uterine blood vessels over this period it is proposed that the myometrial muscle cells are the probable source of the prostacyclin-like material.
将妊娠大鼠子宫的子宫肌层、蜕膜和子宫外血管切碎后，在室温下孵育可产生一种类前列环素物质。在两个检测系统中，将孵育混合物中的活性与纯前列环素进行比较：牛冠状动脉条的舒张和对ADP诱导的富含兔血小板血浆聚集的抑制。根据对血小板聚集的抑制作用估计的结果表明，在妊娠第12天，所有样本产生的活性都很低（低于0.25 ng/mg）。然而，在分娩时（第22天），子宫肌层的合成增加了18.5倍，超过3 ng/mg前列环素，而蜕膜的产生仅增加了5倍。由于在此期间子宫外血管的合成没有增加，因此有人提出子宫肌层肌细胞可能是类前列环素物质的来源。
